Vascular cell adhesion molecule‑1 levels in patients with coronary artery disease with type 2 diabetes mellitus

Chronic systemic inflammation is a key component of the pathogenesis both type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). Soluble vascular cell adhesion molecule‑1 (sVCAM‑1) considered as indicator endothelial activation. The aim our study was to investigate sVCAM‑1 levels in patients with CAD T2DM determine their dependence on previous history myocardial infarction (MI). included 52 stable T2DM, 20 without 14 control group persons. sVCAM-1 were measured serum by enzyme-linked immunosorbent assay. higher than (p<0,001 p<0,001, respectively). difference between not significant (p=0,355). There no correlations glucometabolic indices any group. Only level negatively correlated high-density lipoprotein cholesterol. (MI) had MI (p=0,038, р=0,043, diabetic increased those (р=0,036, comparison controls). left ventricular remodeling either or MI. Conclusions. In controls. However, only absence there further increase its postinfarction cardiosclerosis.